Rada-Iglesias lab

Developmental genomics

 

Center for Molecular Medicine Cologne (CMMC)


The CMMC is a multidisciplinary center at the University of Cologne that brings together physician scientists with basic researchers. The mission of the CMMC is to advance the understanding of the underlying molecular and cellular mechanisms of many common health problems. CMMC along with its partner institutes such as the Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (CECAD), the Cologne Center for Genomics and the Max-Planck Institute for Biology of Aging, are all located within the same campus, providing a vibrant, multidisciplinary and highly collaborative scientific environment. As a result, the CMMC provides an excellent platform for our “Developmental Genomics” Junior Research Group, with access to state-of-the-art technologies and a broad scientific community. For further information, visit www.zmmk.uni-koeln.de.


The CMMC is located in Cologne, the fourth-largest city in Germany and host of one of the oldest and largest universities in Europe. Cologne is one of the major German cultural hubs, with a vibrant, international and lively atmosphere. Located in the heart of Europe, Cologne is within driving distance of several major German and European cities and very close to several international airports. For further information, visit http://www.cologne.de/

News
18/05/17 Sara de la Cruz's work on poised enhancers regulatory topology and function was awarded with the poster prize at the 9th International Meeting of the Stem Cell Network!!!
01/05/17 Do not miss Michaela’s talk at the 9th International Meeting of the Stem Cell Network NRW taking place in Muenster (Germany) May 16 – 17, 2017 
01/05/17 Tomás Pachano, awarded with the DAAD fellowship, has joined the lab , welcome!!
10/03/17 Great paper Sara, congratulations!! Cell Stem Cell 2017
03/03/17 Alvaro will be participating in the following seminars:
April 20th: Invited speaker: Inserm workshop - ‘Enhancer structure and function’; Bordeaux, France.
May 10th: Invited speaker at the Center for Genomic Regulation (CRG), Barcelona, Spain.
22/12/16 Congratulations Miloš on your new publication!! Hum Mol Genet. 2016 Dec 22
13/12/16 Rizwan’s paper is out!! Cell Reports, Dec 13th 2016 
05/12/16 We are now part of the SFB829 Research Consortium focused on  the "Molecular Mechanisms Regulating Skin Homeostasis". As part of the SF829, we were recently awarded with a grant to identify and characterize major stem cell regulators within the epidermis.
05/12/16 On January 16th, 2017 Alvaro will be presenting at the IBMP in Barcelona (Spain). Title: "Chromatin signatures as powerful tools to functionally annotate vertebrate genomes"
01/12/16 Check out Alvaro’s interview in Cell Stem Cell 2016 Dec 1st

News

18/05/17 Sara de la Cruz's work on poised enhancers regulatory topology and function was awarded with the poster prize at the 9th International Meeting of the Stem Cell Network!!!

01/05/17 Do not miss Michaela’s talk at the 9th International Meeting of the Stem Cell Network NRW taking place in Muenster (Germany) May 16 – 17, 2017

01/05/17 Tomás Pachano, awarded with the DAAD fellowship, has joined the lab , welcome!!

10/03/17 Great paper Sara, congratulations!! Cell Stem Cell 2017

03/03/17 Alvaro will be participating in the following seminars:

April 20th: Invited speaker: Inserm workshop - ‘Enhancer structure and function’; Bordeaux, France.

May 10th: Invited speaker at the Center for Genomic Regulation (CRG), Barcelona, Spain.

22/12/16 Congratulations Miloš on your new publication!! Hum Mol Genet. 2016 Dec 22

13/12/16 Rizwan’s paper is out!! Cell Reports, Dec 13th 2016

05/12/16 We are now part of the SFB829 Research Consortium focused on  the "Molecular Mechanisms Regulating Skin Homeostasis". As part of the SF829, we were recently awarded with a grant to identify and characterize major stem cell regulators within the epidermis.

05/12/16 On January 16th, 2017 Alvaro will be presenting at the IBMP in Barcelona (Spain). Title: "Chromatin signatures as powerful tools to functionally annotate vertebrate genomes"

01/12/16 Check out Alvaro’s interview in Cell Stem Cell 2016 Dec 1st


Research overview

The main interest of our laboratory is to uncover the genetic and epigenetic factors controlling the deployment of gene expression programs during vertebrate embryogenesis. Towards this goal, we are using a multidisciplinary approach that combines in vitro and in vivo models with biochemical, genomic and genetic engineering tools.

Inspired by our work on vertebrate embryogenesis, we are applying similar experimental approaches to uncover the molecular basis of human congenital diseases. More specifically, we are investigating how genetic variants and genomic re-arrangements can lead to human disease through the disruption of gene regulatory landscapes.

Our major future aim is to investigate the pathological consequences of the disruption of transcriptionally regulatory networks.

Jürgen Schmidt