Rada-Iglesias lab

Developmental genomics

 

Center for Molecular Medicine Cologne (CMMC)


The CMMC is a multidisciplinary center at the University of Cologne that brings together physician scientists with basic researchers. The mission of the CMMC is to advance the understanding of the underlying molecular and cellular mechanisms of many common health problems. CMMC along with its partner institutes such as the Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (CECAD), the Cologne Center for Genomics and the Max-Planck Institute for Biology of Aging, are all located within the same campus, providing a vibrant, multidisciplinary and highly collaborative scientific environment. As a result, the CMMC provides an excellent platform for our “Developmental Genomics” Junior Research Group, with access to state-of-the-art technologies and a broad scientific community. For further information, visit www.zmmk.uni-koeln.de.


The CMMC is located in Cologne, the fourth-largest city in Germany and host of one of the oldest and largest universities in Europe. Cologne is one of the major German cultural hubs, with a vibrant, international and lively atmosphere. Located in the heart of Europe, Cologne is within driving distance of several major German and European cities and very close to several international airports. For further information, visit http://www.cologne.de/

News
03/07/17 Michaela Bartusel and Sara de la Cruz Molina will be presenting their latest work at the Mechanisms of Eukaryotic Transcription Meeting in CSHL, NY, USA.
20/06/17 If your are interested in what is happening in our lab be aware of the following dates and places where Alvaro will be presenting:
June 23rd: seminar at Max Planck Institute for Molecular Genetics, Berlin, Germany
7-10 September: invited speaker at EMBO Conference "Gene regulatory mechanisms in neural fate decisions", San Juan de Alicante, Spain
23-26 October: invited speaker at the Annual Congress of the Spanish Biochemical and Molecular Biology Society, Barcelona, Spain
November 10th: seminar at GENYO, Granada, Spain
18/05/17 Sara de la Cruz's work on poised enhancers regulatory topology and function was awarded with the poster prize at the 9th International Meeting of the Stem Cell Network NRW!!!
01/05/17 Do not miss Michaela’s talk at the 9th International Meeting of the Stem Cell Network NRW taking place in Muenster (Germany) May 16 – 17, 2017 
01/05/17 Tomás Pachano, awarded with the DAAD fellowship, has joined the lab , welcome!!
10/03/17 Great paper Sara, congratulations!! Cell Stem Cell 2017

News

03/07/17 Michaela Bartusel and Sara de la Cruz Molina will be presenting their latest work at the Mechanisms of Eukaryotic Transcription Meeting in CSHL, NY, USA.

20/06/17 If your are interested in what is happening in our lab be aware of the following dates and places where Alvaro will be presenting:

June 23rd: seminar at Max Planck Institute for Molecular Genetics, Berlin, Germany

7-10 September: invited speaker at EMBO Conference "Gene regulatory mechanisms in neural fate decisions", San Juan de Alicante, Spain

23-26 October: invited speaker at the Annual Congress of the Spanish Biochemical and Molecular Biology Society, Barcelona, Spain

November 10th: seminar at GENYO, Granada, Spain

18/05/17 Sara de la Cruz's work on poised enhancers regulatory topology and function was awarded with the poster prize at the 9th International Meeting of the Stem Cell Network NRW!!!

01/05/17 Do not miss Michaela’s talk at the 9th International Meeting of the Stem Cell Network NRW taking place in Muenster (Germany) May 16 – 17, 2017

01/05/17 Tomás Pachano, awarded with the DAAD fellowship, has joined the lab , welcome!!

10/03/17 Great paper Sara, congratulations!! Cell Stem Cell 2017

Research overview

The main interest of our laboratory is to uncover the genetic and epigenetic factors controlling the deployment of gene expression programs during vertebrate embryogenesis. Towards this goal, we are using a multidisciplinary approach that combines in vitro and in vivo models with biochemical, genomic and genetic engineering tools.

Inspired by our work on vertebrate embryogenesis, we are applying similar experimental approaches to uncover the molecular basis of human congenital diseases. More specifically, we are investigating how genetic variants and genomic re-arrangements can lead to human disease through the disruption of gene regulatory landscapes.

Our major future aim is to investigate the pathological consequences of the disruption of transcriptionally regulatory networks.

Jürgen Schmidt